The closest major airport is Denver International Airport, also known as DEN or KDEN, located in Denver, Colorado, at a driving distance of 111 miles from the city center of Laramie, WY, which can be made in approximately 2 hours and 22 minutes.
The city of Laramie is served by the Greyhound Lines, which also have a bus depot in the city, as well as by the Great Lakes Airlines, which provide daily commercial flights between Laramie Regional Airport and Denver, CO. There aren't many local transportation choices to get around in Laramie, and people say that a car is a must-have, here. However, there is a bus which runs from the truck stop area, to downtown Laramie, which you can use to travel inside the city (if you're willing to wait one hour for it to arrive).
Easy! Just follow the driving directions listed below!
From Denver International Airport: Start by heading south on Newbern Street, which in some point, turns slightly right, becoming E 96th Avenue. Make a right at Vandriver Street, and another right at E 80th Avenue. Make the 1st left, onto Harry B Combs Parkway/Undergrove Street, and continue to drive, onto E 75th Avenue. Make a right at Jackson Gap Road, and then a left, onto Pena Boulevard. Take exit 6B, toward Boulder/Ft. Collins, and merge onto E-470 N. Take the exit 47, to merge onto I-25 N, toward Ft. Collins, and enter Wyoming. Take the exit 8B to merge onto I-80 W, toward Laramie. Take the exit 316 for I-80/US-30 W/Grand Avenue. Merge onto Grand Avenue/I-80 Bus W/US-30 W. Make a right at S 13th Street, and take the 1st left onto E Ivinson Avenue. The university is located on your right.